What could easily be the most important advance in the pharmacologic treatment of major depression and anxiety disorders is now unfolding.
A new investigational drug, currently known as ALKS 5461, could deliver all the mood-enhancing and anxiety-lowering effects that lead people to use opiates like heroin and Oxycontin—without the potential for getting high or addicted. That’s right: ALKS 5461 could be a non-abusable, non-addictive heroin-like compound.
ALKS 5461 is actually a combination of two molecules. The first is buprenorphine, which is already used to provide some of the benefits of opiates, without many of the worst side effects, allowing people to get off of street drugs (as an alternative to methadone). The second molecule is now known as ALKS 33—and that’s the magic part.
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